Fungal Biofilms

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Fungal Biofilms

• They are responsible for a broad spectrum of microbial infections in the human host [1] • Candida albicans and Candida parapsilosis biofilms are relatively resistant to fluconazole, amphotericin B, nystatin, voriconazole and others [2]. • Aspergillus fumigatus biofilms are relatively resistant to itraconazole and, to some extent, to caspofungin [3]. • Cryptococcal biofilms are unaffected by f...

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Pearls Fungal Biofilms

Biofilms are a principal form of microbial growth and are critical to development of clinical infection. They are responsible for a broad spectrum of microbial infections in the human host. Many medically important fungi produce biofilms, including Candida [1], Aspergillus [2], Cryptococcus [3], Trichosporon [4], Coccidioides [5], and Pneumocystis [6]. In this review we emphasize common feature...

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Bacterial biofilm formation on fungi participates in the synergistic degradation of substrates, antagonism of fungal growth, bacterial utilization of fungi as nutrient sources, and the formation of more complex synergistic associations for the purposes of nutrient acquisition. While bacterial biofilm formation has been described in many systems, the molecular mechanisms that govern these intera...

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Fungal Biofilms and Drug Resistance

Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring on devices such as indwelling intravascular catheters. Fungal biofilm-associated infections are frequently refractory to conventional therapy b...

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Highlights in pathogenic fungal biofilms.

A wide variety of fungi have demonstrated the ability to colonize surfaces and form biofilms. Most studies on fungal biofilms have focused on Candida albicans and more recently, several authors have reported the involvement of other genera of yeasts and Candida species, as well as of filamentous fungi in the formation of biofilms, including: Cryptococcus neoformans, Cryptococcus gattii, Rhodoto...

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ژورنال

عنوان ژورنال: PLoS Pathogens

سال: 2012

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1002585